IFT172

Entrez Summary: This gene encodes a subunit of the intraflagellar transport subcomplex IFT-B. Subcomplexes IFT-A and IFT-B are necessary for ciliary assembly and maintenance. Mutations in this gene have been associated with skeletal ciliopathies, with or without polydactyly, such as such short-rib thoracic dysplasias 1, 9 or 10. [provided by RefSeq, Mar 2014].
UniProt Summary: Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sperm cytoplasmic droplet
hindgut development
left/right axis specification
left/right pattern formation
intraciliary transport particle B
sperm principal piece
sperm midpiece
positive regulation of smoothened signaling pathway
spinal cord motor neuron differentiation
intraciliary transport involved in cilium assembly
ciliary tip
non-motile cilium assembly
ventral spinal cord development
intraciliary transport
cytoplasmic microtubule organization
cell differentiation in spinal cord
extracellular vesicle
heart looping
determination of heart left/right asymmetry
embryonic heart tube morphogenesis
protein transport along microtubule
microtubule-based protein transport
smoothened signaling pathway
embryonic heart tube development
regulation of smoothened signaling pathway
dorsal/ventral pattern formation
axis specification
roof of mouth development
neural tube closure
tube closure
primary neural tube formation
axoneme
neural tube formation
spinal cord development
determination of left/right symmetry
determination of bilateral symmetry
embryonic epithelial tube formation
negative regulation of epithelial cell proliferation
specification of symmetry
Notch signaling pathway