IFT57 [The Human Chemical-Genetic Interaction Map Project]

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======= IFT57 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFT57
  * **<color #00a2e8>Official Name</color>**: intraflagellar transport 57
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55081|55081]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWB7|Q9NWB7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFT57&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFT57|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. {ECO:0000250, ECO:0000269|PubMed:11788820, ECO:0000269|PubMed:17107665, ECO:0000269|PubMed:17623017}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IFT57|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dendrite terminus|
|left/right pattern formation|
|intraciliary transport particle B|
|motile cilium assembly|
|photoreceptor connecting cilium|
|intraciliary transport involved in cilium assembly|
|ciliary tip|
|non-motile cilium assembly|
|intraciliary transport|
|heart looping|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|protein transport along microtubule|
|microtubule-based protein transport|
|smoothened signaling pathway|
|embryonic heart tube development|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|axoneme|
|neural tube formation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|embryonic epithelial tube formation|
|negative regulation of epithelial cell proliferation|
|specification of symmetry|
|epithelial tube formation|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|ciliary basal body|
|morphogenesis of embryonic epithelium|
|tube formation|
|positive regulation of cysteine-type endopeptidase activity|
|transport along microtubule|
|neural tube development|
|positive regulation of endopeptidase activity|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|positive regulation of peptidase activity|
|cilium|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of cysteine-type endopeptidase activity|
|heart morphogenesis|
|protein-containing complex localization|
|microtubule-based movement|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|regionalization|
|regulation of epithelial cell proliferation|
|cilium assembly|
|positive regulation of proteolysis|
|cilium organization|
|regulation of endopeptidase activity|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|regulation of peptidase activity|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|centrosome|
|heart development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|microtubule-based process|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|regulation of proteolysis|
|organelle assembly|
|positive regulation of hydrolase activity|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|apoptotic process|
|animal organ morphogenesis|
|embryo development|
|Golgi apparatus|
|intracellular protein transport|
|programmed cell death|
|cell death|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|DNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|regulation of cell death|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8934
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFT57 Expression in NALM6 Cells: 2.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>