IFT57

Entrez Summary: N/A
UniProt Summary: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. {ECO:0000250, ECO:0000269|PubMed:11788820, ECO:0000269|PubMed:17107665, ECO:0000269|PubMed:17623017}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UM0125461 0.74μM R02 exp84	-2
Trientine 500μM R08 exp534	1.78

dendrite terminus
left/right pattern formation
intraciliary transport particle B
motile cilium assembly
photoreceptor connecting cilium
intraciliary transport involved in cilium assembly
ciliary tip
non-motile cilium assembly
intraciliary transport
heart looping
determination of heart left/right asymmetry
embryonic heart tube morphogenesis
protein transport along microtubule
microtubule-based protein transport
smoothened signaling pathway
embryonic heart tube development
activation of cysteine-type endopeptidase activity involved in apoptotic process
neural tube closure
tube closure
primary neural tube formation
axoneme
neural tube formation
determination of left/right symmetry
determination of bilateral symmetry
embryonic epithelial tube formation
negative regulation of epithelial cell proliferation
specification of symmetry
epithelial tube formation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
ciliary basal body
morphogenesis of embryonic epithelium
tube formation
positive regulation of cysteine-type endopeptidase activity
transport along microtubule
neural tube development
positive regulation of endopeptidase activity
cytoskeleton-dependent intracellular transport
microtubule-based transport
positive regulation of peptidase activity
cilium