IFT74 [The Human Chemical-Genetic Interaction Map Project]

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======= IFT74 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFT74
  * **<color #00a2e8>Official Name</color>**: intraflagellar transport 74
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80173|80173]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96LB3|Q96LB3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFT74&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFT74|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608040|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis. {ECO:0000269|PubMed:23990561}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|keratinocyte development|
|positive regulation of cell adhesion mediated by integrin|
|intraciliary transport particle B|
|beta-tubulin binding|
|intraciliary transport involved in cilium assembly|
|ciliary tip|
|non-motile cilium assembly|
|regulation of cell adhesion mediated by integrin|
|intraciliary transport|
|microtubule-based protein transport|
|protein transport along microtubule|
|motile cilium|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|negative regulation of epithelial cell proliferation|
|specification of symmetry|
|Notch signaling pathway|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|epithelial cell development|
|cilium|
|cytoplasmic vesicle|
|protein-containing complex localization|
|microtubule-based movement|
|keratinocyte differentiation|
|epidermal cell differentiation|
|regulation of epithelial cell proliferation|
|cilium assembly|
|cilium organization|
|skin development|
|chromatin binding|
|positive regulation of cell adhesion|
|epidermis development|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|centrosome|
|heart development|
|microtubule-based process|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of cell adhesion|
|organelle assembly|
|circulatory system development|
|intracellular protein transport|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of RNA metabolic process|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.98|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.75|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.74|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.71|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.74|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.74|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.84|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.98|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.02|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.16|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.21|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.31|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10227
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFT74 Expression in NALM6 Cells: 1.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>