IFT74

• Official Symbol: IFT74
• Official Name: intraflagellar transport 74
• Aliases and Previous Symbols: N/A
• Entrez ID: 80173
• UniProt: Q96LB3
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis–frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017].
• UniProt Summary: Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis. {ECO:0000269|PubMed:23990561}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 10227
• Expression level (log2 read counts): 1.84

Expression Distribution

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IFT74 Expression in NALM6 Cells: 1.84