IFT88 [The Human Chemical-Genetic Interaction Map Project]

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======= IFT88 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFT88
  * **<color #00a2e8>Official Name</color>**: intraflagellar transport 88
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8100|8100]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13099|Q13099]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFT88&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFT88|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600595|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. {ECO:0000250|UniProtKB:Q61371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Apc3|
|TPR 1|
|DUF3808|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intraciliary transport particle B|
|inner ear receptor cell stereocilium organization|
|non-motile cilium|
|regulation of autophagosome assembly|
|ciliary base|
|intraciliary transport involved in cilium assembly|
|inner ear receptor cell development|
|kinesin binding|
|regulation of vacuole organization|
|sperm flagellum|
|non-motile cilium assembly|
|ciliary tip|
|intraciliary transport|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|microtubule-based protein transport|
|protein transport along microtubule|
|regulation of cilium assembly|
|motile cilium|
|ciliary basal body|
|centriole|
|transport along microtubule|
|regulation of macroautophagy|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|inner ear development|
|cilium|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of organelle assembly|
|ear development|
|protein-containing complex localization|
|kidney development|
|microtubule-based movement|
|renal system development|
|urogenital system development|
|regulation of autophagy|
|cilium assembly|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|centrosome|
|sensory organ development|
|neuron projection development|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|organelle assembly|
|neuron development|
|regulation of cellular catabolic process|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|intracellular protein transport|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.79|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10761
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFT88 Expression in NALM6 Cells: 3.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>