IFT88

Entrez Summary: N/A
UniProt Summary: Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. {ECO:0000250|UniProtKB:Q61371}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Dynasore 7μM R08 exp436	-1.79
Salinomycin 3.5μM R08 exp521	1.76

intraciliary transport particle B
inner ear receptor cell stereocilium organization
non-motile cilium
regulation of autophagosome assembly
ciliary base
intraciliary transport involved in cilium assembly
inner ear receptor cell development
kinesin binding
regulation of vacuole organization
sperm flagellum
non-motile cilium assembly
ciliary tip
intraciliary transport
inner ear receptor cell differentiation
mechanoreceptor differentiation
microtubule-based protein transport
protein transport along microtubule
regulation of cilium assembly
motile cilium
ciliary basal body
centriole
transport along microtubule
regulation of macroautophagy
cytoskeleton-dependent intracellular transport
microtubule-based transport
inner ear development
cilium
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of organelle assembly
ear development
protein-containing complex localization
kidney development
microtubule-based movement
renal system development
urogenital system development
regulation of autophagy
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly