IGBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= IGBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IGBP1
  * **<color #00a2e8>Official Name</color>**: immunoglobulin binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3476|3476]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78318|P78318]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IGBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IGBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300139|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. {ECO:0000269|PubMed:19818709, ECO:0000269|PubMed:23591866}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TAP42|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of microtubule-based movement|
|protein phosphatase 2A binding|
|protein phosphatase regulator activity|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|B cell activation|
|negative regulation of MAPK cascade|
|regulation of phosphatase activity|
|response to interleukin-1|
|regulation of dephosphorylation|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of microtubule-based process|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|response to tumor necrosis factor|
|negative regulation of proteolysis|
|lymphocyte activation|
|negative regulation of protein phosphorylation|
|regulation of endopeptidase activity|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|negative regulation of intracellular signal transduction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|regulation of cellular component movement|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|cell activation|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of cell death|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.16|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.07|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.07|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.91|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.87|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.85|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.77|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.92|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|2.23|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.25|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.3|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 444/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|20/28|
|blood|19/26|
|bone|17/25|
|breast|23/30|
|central nervous system|27/49|
|cervix|2/4|
|colorectal|15/17|
|esophagus|2/11|
|fibroblast|0/1|
|gastric|12/14|
|kidney|7/18|
|liver|10/19|
|lung|42/72|
|lymphocyte|11/14|
|ovary|15/25|
|pancreas|7/22|
|peripheral nervous system|11/15|
|plasma cell|9/12|
|prostate|1/1|
|skin|17/20|
|soft tissue|3/7|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|15/28|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2249
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IGBP1 Expression in NALM6 Cells: 5.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>