IGBP1

Gene Information

Official Symbol: IGBP1
Official Name: immunoglobulin binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 3476
UniProt: P78318
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008].
UniProt Summary: Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. {ECO:0000269|PubMed:19818709, ECO:0000269|PubMed:23591866}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Atovaquone 15μM R08 exp451	-2.16
Docosahexaenoic-acid 50μM R07 exp356	-2.07
GSK-J4 1.5μM R08 exp441	-2.07
CB-5083 0.4μM R08 exp468	-1.91
BI-6727 0.001μM R01 exp42	-1.87
Pimelic-diphenylamide-106 5μM R00 exp28	-1.85
BVD-523 15μM R02 exp67	1.77
Tunicamycin 0.04μM R07 exp418	1.92
CHIR-124 0.04μM R06 exp272	2.23
RO-3307 4.7μM R02 exp80	2.25
Salinomycin 3.5μM R08 exp521	2.3
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.38

Global Fraction of Cell Lines Where Essential: 444/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	20/28
blood	19/26
bone	17/25
breast	23/30
central nervous system	27/49
cervix	2/4
colorectal	15/17
esophagus	2/11
fibroblast	0/1
gastric	12/14
kidney	7/18
liver	10/19
lung	42/72
lymphocyte	11/14
ovary	15/25
pancreas	7/22
peripheral nervous system	11/15
plasma cell	9/12
prostate	1/1
skin	17/20
soft tissue	3/7
thyroid	1/2
upper aerodigestive	14/22
urinary tract	15/28
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 2249
Expression level (log2 read counts): 5.06

Expression Distribution

regulation of microtubule-based movement
protein phosphatase 2A binding
protein phosphatase regulator activity
negative regulation of stress-activated protein kinase signaling cascade
negative regulation of stress-activated MAPK cascade
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cysteine-type endopeptidase activity
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
B cell activation
negative regulation of MAPK cascade
regulation of phosphatase activity
response to interleukin-1
regulation of dephosphorylation
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of microtubule-based process
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
negative regulation of peptidase activity
response to tumor necrosis factor
negative regulation of proteolysis
lymphocyte activation
negative regulation of protein phosphorylation
regulation of endopeptidase activity
negative regulation of phosphorylation
regulation of peptidase activity
negative regulation of hydrolase activity
negative regulation of intracellular signal transduction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of proteolysis
regulation of cellular response to stress
regulation of MAPK cascade
negative regulation of catalytic activity
negative regulation of transcription by RNA polymerase II
negative regulation of apoptotic process
negative regulation of programmed cell death