IGFALS

• Official Symbol: IGFALS
• Official Name: insulin like growth factor binding protein acid labile subunit
• Aliases and Previous Symbols: N/A
• Entrez ID: 3483
• UniProt: P35858
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
• UniProt Summary: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 3447
• Expression level (log2 read counts): -3.08

Expression Distribution

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IGFALS Expression in NALM6 Cells: -3.08