IGFBP6

Entrez Summary: N/A
UniProt Summary: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

insulin-like growth factor binary complex
insulin-like growth factor II binding
insulin-like growth factor I binding
regulation of insulin-like growth factor receptor signaling pathway
fibronectin binding
negative regulation of canonical Wnt signaling pathway
negative regulation of Wnt signaling pathway
regulation of canonical Wnt signaling pathway
signaling receptor binding
regulation of Wnt signaling pathway
negative regulation of cell population proliferation
Golgi apparatus
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
extracellular space
regulation of cell population proliferation
negative regulation of response to stimulus
extracellular region