IGFBP7

Entrez Summary: This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011].
UniProt Summary: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. {ECO:0000269|PubMed:8117260, ECO:0000269|PubMed:8939990}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

response to cortisol
insulin-like growth factor binding
embryo implantation
regulation of steroid biosynthetic process
response to retinoic acid
response to heat
regulation of steroid metabolic process
extracellular matrix structural constituent
response to glucocorticoid
response to corticosteroid
response to temperature stimulus
female pregnancy
regulation of lipid biosynthetic process
response to ketone
multi-multicellular organism process
response to alcohol
endoplasmic reticulum lumen
response to steroid hormone
response to acid chemical
post-translational protein modification
collagen-containing extracellular matrix
regulation of lipid metabolic process
regulation of cell growth
cellular response to hormone stimulus
regulation of growth
negative regulation of cell population proliferation
response to lipid
response to hormone
response to organic cyclic compound
cell adhesion
biological adhesion
multi-organism reproductive process
response to drug
response to abiotic stimulus
cellular response to endogenous stimulus
reproductive process
reproduction
response to endogenous stimulus
response to oxygen-containing compound
extracellular space