IL12RB2 [The Human Chemical-Genetic Interaction Map Project]

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======= IL12RB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL12RB2
  * **<color #00a2e8>Official Name</color>**: interleukin 12 receptor subunit beta 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3595|3595]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99665|Q99665]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL12RB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL12RB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601642|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL6Ra-bind|
|fn3|
|Lep receptor Ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-35-mediated signaling pathway|
|interferon-gamma production|
|cytokine binding|
|interleukin-12-mediated signaling pathway|
|cytokine receptor activity|
|cellular response to interleukin-12|
|response to interleukin-12|
|positive regulation of interferon-gamma production|
|regulation of interferon-gamma production|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|cytokine production|
|receptor complex|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|external side of plasma membrane|
|positive regulation of cytokine production|
|protein kinase binding|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|response to lipid|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|protein phosphorylation|
|cellular response to cytokine stimulus|
|response to cytokine|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|integral component of plasma membrane|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|positive regulation of multicellular organismal process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15094
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL12RB2 Expression in NALM6 Cells: 1.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>