IL12RB2

Entrez Summary: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012].
UniProt Summary: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

interleukin-35-mediated signaling pathway
interferon-gamma production
cytokine binding
interleukin-12-mediated signaling pathway
cytokine receptor activity
cellular response to interleukin-12
response to interleukin-12
positive regulation of interferon-gamma production
regulation of interferon-gamma production
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
cytokine production
receptor complex
response to lipopolysaccharide
response to molecule of bacterial origin
external side of plasma membrane
positive regulation of cytokine production
protein kinase binding
cytokine-mediated signaling pathway
response to bacterium
regulation of cytokine production
response to lipid
peptidyl-amino acid modification
positive regulation of cell population proliferation
protein phosphorylation
cellular response to cytokine stimulus
response to cytokine
phosphorylation
response to other organism
response to external biotic stimulus
response to biotic stimulus
integral component of plasma membrane
response to oxygen-containing compound
regulation of cell population proliferation
positive regulation of multicellular organismal process