IL13RA2

Gene Information

Official Symbol: IL13RA2
Official Name: interleukin 13 receptor subunit alpha 2
Aliases and Previous Symbols: N/A
Entrez ID: 3598
UniProt: Q14627
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008].
UniProt Summary: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). {ECO:0000269|PubMed:20223216}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18885
Expression level (log2 read counts): -7.68

Expression Distribution

negative regulation of mast cell degranulation
negative regulation of mast cell activation involved in immune response
negative regulation of myeloid leukocyte mediated immunity
negative regulation of immunoglobulin production
negative regulation of leukocyte degranulation
negative regulation of mast cell activation
negative regulation of regulated secretory pathway
negative regulation of exocytosis
regulation of mast cell degranulation
regulation of mast cell activation involved in immune response
negative regulation of production of molecular mediator of immune response
cytokine binding
regulation of mast cell activation
cytokine receptor activity
regulation of leukocyte degranulation
negative regulation of leukocyte mediated immunity
regulation of myeloid leukocyte mediated immunity
negative regulation of intracellular transport
regulation of immunoglobulin production
negative regulation of immune effector process
regulation of production of molecular mediator of immune response
negative regulation of immune response
regulation of regulated secretory pathway
negative regulation of leukocyte activation
negative regulation of cell activation
negative regulation of secretion by cell
receptor complex
regulation of leukocyte mediated immunity
immunoglobulin mediated immune response
B cell mediated immunity
positive regulation of immune effector process
regulation of exocytosis
negative regulation of secretion
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of intracellular transport
external side of plasma membrane
negative regulation of immune system process
regulation of immune effector process
negative regulation of transport