IL18
Gene Information
- Official Symbol: IL18
- Official Name: interleukin 18
- Aliases and Previous Symbols: N/A
- Entrez ID: 3606
- UniProt: Q14116
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011].
- UniProt Summary: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
Pfam Domains GO Terms
Pfam Domains
| IL1 |
GO Terms
| granulocyte macrophage colony-stimulating factor biosynthetic process |
| chemokine metabolic process |
| interleukin-18 receptor binding |
| chemokine biosynthetic process |
| interleukin-13 biosynthetic process |
| interferon-gamma biosynthetic process |
| granulocyte macrophage colony-stimulating factor production |
| interleukin-2 biosynthetic process |
| interleukin-13 production |
| T-helper 1 cell cytokine production |
| positive regulation of NK T cell proliferation |
| regulation of NK T cell proliferation |
| regulation of T-helper 1 cell cytokine production |
| positive regulation of T-helper 1 cell cytokine production |
| positive regulation of T-helper 2 cell differentiation |
| cellular response to interleukin-18 |
| positive regulation of natural killer cell proliferation |
| interleukin-18-mediated signaling pathway |
| CD4-positive, alpha-beta T cell cytokine production |
| positive regulation of NK T cell activation |
| type 2 immune response |
| regulation of natural killer cell proliferation |
| chemokine production |
| interleukin-2 production |
| response to interleukin-18 |
| regulation of NK T cell activation |
| T cell cytokine production |
| regulation of T-helper 2 cell differentiation |
| interleukin-6 production |
| positive regulation of granulocyte macrophage colony-stimulating factor production |
| positive regulation of neuroinflammatory response |
| sleep |
| cytokine biosynthetic process |
| cytokine metabolic process |
| regulation of granulocyte macrophage colony-stimulating factor production |
| positive regulation of type 2 immune response |
| positive regulation of macrophage derived foam cell differentiation |
| positive regulation of interleukin-17 production |
| positive regulation of alpha-beta T cell proliferation |
| interferon-gamma production |
| positive regulation of T cell cytokine production |
| T-helper 1 type immune response |
| positive regulation of T-helper 1 type immune response |
| positive regulation of natural killer cell activation |
| positive regulation of T-helper cell differentiation |
| positive regulation of activated T cell proliferation |
| cytokine production involved in immune response |
| negative regulation of myoblast differentiation |
| natural killer cell mediated cytotoxicity |
| regulation of T-helper 1 type immune response |
| natural killer cell mediated immunity |
| regulation of macrophage derived foam cell differentiation |
| regulation of interleukin-17 production |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| regulation of type 2 immune response |
| regulation of alpha-beta T cell proliferation |
| regulation of neuroinflammatory response |
| positive regulation of tissue remodeling |
| regulation of T cell cytokine production |
| activation of protein kinase B activity |
| regulation of natural killer cell activation |
| lipopolysaccharide-mediated signaling pathway |
| regulation of T-helper cell differentiation |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| acylglycerol homeostasis |
| triglyceride homeostasis |
| regulation of activated T cell proliferation |
| leukocyte mediated cytotoxicity |
| T cell mediated immunity |
| positive regulation of alpha-beta T cell differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of T cell mediated immunity |
| regulation of myoblast differentiation |
| positive regulation of cytokine production involved in immune response |
| natural killer cell activation |
| regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| positive regulation of interferon-gamma production |
| positive regulation of tyrosine phosphorylation of STAT protein |
| regulation of T cell mediated immunity |
| regulation of tissue remodeling |
| positive regulation of NIK/NF-kappaB signaling |
| regulation of tyrosine phosphorylation of STAT protein |
| cholesterol homeostasis |
| sterol homeostasis |
| positive regulation of T cell differentiation |
| positive regulation of receptor signaling pathway via JAK-STAT |
| regulation of cytokine production involved in immune response |
| positive regulation of smooth muscle cell proliferation |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| positive regulation of receptor signaling pathway via STAT |
| cell killing |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| positive regulation of T cell proliferation |
| positive regulation of production of molecular mediator of immune response |
| positive regulation of cold-induced thermogenesis |
| regulation of interferon-gamma production |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of adaptive immune response |
| positive regulation of lymphocyte mediated immunity |
| regulation of NIK/NF-kappaB signaling |
| regulation of phosphatidylinositol 3-kinase signaling |
| positive regulation of lymphocyte proliferation |
| regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of mononuclear cell proliferation |
| regulation of smooth muscle cell proliferation |
| lipid homeostasis |
| positive regulation of leukocyte mediated immunity |
| regulation of receptor signaling pathway via STAT |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| positive regulation of inflammatory response |
| regulation of production of molecular mediator of immune response |
| regulation of cold-induced thermogenesis |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of leukocyte differentiation |
| regulation of lymphocyte mediated immunity |
| cytokine production |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of T cell proliferation |
| regulation of adaptive immune response |
| positive regulation of protein kinase B signaling |
| regulation of lymphocyte differentiation |
| cytokine activity |
| production of molecular mediator of immune response |
| cellular response to lipopolysaccharide |
| positive regulation of hemopoiesis |
| positive regulation of peptidyl-tyrosine phosphorylation |
| cellular response to molecule of bacterial origin |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| cellular response to biotic stimulus |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of protein kinase B signaling |
| regulation of leukocyte proliferation |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| positive regulation of DNA-binding transcription factor activity |
| lymphocyte mediated immunity |
| regulation of leukocyte differentiation |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of leukocyte cell-cell adhesion |
| response to lipopolysaccharide |
| regulation of T cell activation |
| angiogenesis |
| response to molecule of bacterial origin |
| activation of protein kinase activity |
| regulation of inflammatory response |
| positive regulation of lymphocyte activation |
| MAPK cascade |
| lymphocyte activation |
| signal transduction by protein phosphorylation |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| blood vessel morphogenesis |
| positive regulation of cell activation |
| regulation of DNA-binding transcription factor activity |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of immune effector process |
| positive regulation of defense response |
| blood vessel development |
| inflammatory response |
| neutrophil activation |
| granulocyte activation |
| vasculature development |
| regulation of lymphocyte activation |
| cardiovascular system development |
| cellular response to lipid |
| positive regulation of protein kinase activity |
| cellular response to organic cyclic compound |
| cell population proliferation |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| adaptive immune response |
| regulation of cell activation |
| tube morphogenesis |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| negative regulation of cell differentiation |
| regulation of defense response |
| innate immune response |
| leukocyte mediated immunity |
| regulation of protein kinase activity |
| tube development |
| response to lipid |
| positive regulation of immune response |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| leukocyte activation |
| negative regulation of developmental process |
| defense response to other organism |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8400
- Expression level (log2 read counts): 1.19
Expression Distribution
IL18 Expression in NALM6 Cells: 1.19
