IL18RAP [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= IL18RAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL18RAP
  * **<color #00a2e8>Official Name</color>**: interleukin 18 receptor accessory protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8807|8807]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95256|O95256]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL18RAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL18RAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604509|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Within the IL18 receptor complex, does not mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. {ECO:0000269|PubMed:9792649, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-18 receptor activity|
|interleukin-18 receptor complex|
|T-helper 1 cell cytokine production|
|cellular response to interleukin-18|
|interleukin-18-mediated signaling pathway|
|CD4-positive, alpha-beta T cell cytokine production|
|T cell cytokine production|
|response to interleukin-18|
|interleukin-6 production|
|T-helper 1 type immune response|
|interferon-gamma production|
|cytokine production involved in immune response|
|positive regulation of natural killer cell mediated cytotoxicity|
|positive regulation of natural killer cell mediated immunity|
|T cell mediated immunity|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|positive regulation of leukocyte mediated cytotoxicity|
|positive regulation of cell killing|
|cellular response to hydrogen peroxide|
|regulation of leukocyte mediated cytotoxicity|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|cellular response to reactive oxygen species|
|positive regulation of leukocyte mediated immunity|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|positive regulation of NF-kappaB transcription factor activity|
|production of molecular mediator of immune response|
|response to reactive oxygen species|
|regulation of leukocyte mediated immunity|
|cellular response to toxic substance|
|positive regulation of immune effector process|
|cellular response to oxidative stress|
|positive regulation of DNA-binding transcription factor activity|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to antibiotic|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|response to oxidative stress|
|cellular response to drug|
|regulation of DNA-binding transcription factor activity|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|inflammatory response|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|response to inorganic substance|
|cell population proliferation|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|adaptive immune response|
|cytokine-mediated signaling pathway|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|positive regulation of immune response|
|leukocyte activation|
|cellular response to cytokine stimulus|
|response to drug|
|cellular response to oxygen-containing compound|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|defense response|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of molecular function|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.84|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.77|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.86|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.93|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7916
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL18RAP Expression in NALM6 Cells: -3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>