IL18RAP

Gene Information

Official Symbol: IL18RAP
Official Name: interleukin 18 receptor accessory protein
Aliases and Previous Symbols: N/A
Entrez ID: 8807
UniProt: O95256
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014].
UniProt Summary: Within the IL18 receptor complex, does not mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. {ECO:0000269|PubMed:9792649, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 0.1μM R06 exp260	-1.84
THZ531 0.11μM R07 exp409	1.77
Thalidomide 20μM R07 exp406	1.86
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.93
BRD2 inhibitor II 20μM R07 exp341	1.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7916
Expression level (log2 read counts): -3.02

Expression Distribution

interleukin-18 receptor activity
interleukin-18 receptor complex
T-helper 1 cell cytokine production
cellular response to interleukin-18
interleukin-18-mediated signaling pathway
CD4-positive, alpha-beta T cell cytokine production
T cell cytokine production
response to interleukin-18
interleukin-6 production
T-helper 1 type immune response
interferon-gamma production
cytokine production involved in immune response
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated immunity
T cell mediated immunity
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
positive regulation of leukocyte mediated cytotoxicity
positive regulation of cell killing
cellular response to hydrogen peroxide
regulation of leukocyte mediated cytotoxicity
regulation of cell killing
positive regulation of lymphocyte mediated immunity
cellular response to antibiotic
response to hydrogen peroxide
cellular response to reactive oxygen species
positive regulation of leukocyte mediated immunity
cytokine production
regulation of lymphocyte mediated immunity
positive regulation of NF-kappaB transcription factor activity
production of molecular mediator of immune response
response to reactive oxygen species
regulation of leukocyte mediated immunity
cellular response to toxic substance
positive regulation of immune effector process
cellular response to oxidative stress
positive regulation of DNA-binding transcription factor activity
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
response to antibiotic