IL1A [The Human Chemical-Genetic Interaction Map Project]

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======= IL1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL1A
  * **<color #00a2e8>Official Name</color>**: interleukin 1 alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3552|3552]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01583|P01583]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL1|
|IL1 propep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fever generation|
|connective tissue replacement|
|heat generation|
|connective tissue replacement involved in inflammatory response wound healing|
|wound healing involved in inflammatory response|
|inflammatory response to wounding|
|ectopic germ cell programmed cell death|
|programmed cell death involved in cell development|
|positive regulation of interleukin-2 biosynthetic process|
|interleukin-1 receptor binding|
|regulation of interleukin-2 biosynthetic process|
|positive regulation of vascular endothelial growth factor production|
|positive regulation of interleukin-2 production|
|temperature homeostasis|
|signal transduction in absence of ligand|
|extrinsic apoptotic signaling pathway in absence of ligand|
|regulation of vascular endothelial growth factor production|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of signal transduction in absence of ligand|
|acute-phase response|
|response to copper ion|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|positive regulation of mitotic nuclear division|
|regulation of interleukin-2 production|
|copper ion binding|
|positive regulation of nuclear division|
|positive regulation of cytokine biosynthetic process|
|cellular response to heat|
|acute inflammatory response|
|positive regulation of cell division|
|interleukin-1-mediated signaling pathway|
|extrinsic apoptotic signaling pathway|
|tissue remodeling|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of cytokine biosynthetic process|
|response to heat|
|positive regulation of cytokine secretion|
|positive regulation of mitotic cell cycle|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of angiogenesis|
|regulation of mitotic nuclear division|
|regulation of cell division|
|cytokine activity|
|cellular response to interleukin-1|
|response to temperature stimulus|
|positive regulation of vasculature development|
|regulation of nuclear division|
|response to interleukin-1|
|regulation of cytokine secretion|
|negative regulation of apoptotic signaling pathway|
|positive regulation of protein secretion|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|positive regulation of peptide secretion|
|regulation of vasculature development|
|multicellular organismal homeostasis|
|response to metal ion|
|positive regulation of cell cycle|
|regulation of apoptotic signaling pathway|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|wound healing|
|regulation of peptide secretion|
|inflammatory response|
|response to inorganic substance|
|response to wounding|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|regulation of secretion|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|positive regulation of transport|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|response to cytokine|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|regulation of organelle organization|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12043
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL1A Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>