IL1A

Gene Information

Official Symbol: IL1A
Official Name: interleukin 1 alpha
Aliases and Previous Symbols: N/A
Entrez ID: 3552
UniProt: P01583
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008].
UniProt Summary: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12043
Expression level (log2 read counts): -2.01

Expression Distribution

IL1
IL1 propep

fever generation
connective tissue replacement
heat generation
connective tissue replacement involved in inflammatory response wound healing
wound healing involved in inflammatory response
inflammatory response to wounding
ectopic germ cell programmed cell death
programmed cell death involved in cell development
positive regulation of interleukin-2 biosynthetic process
interleukin-1 receptor binding
regulation of interleukin-2 biosynthetic process
positive regulation of vascular endothelial growth factor production
positive regulation of interleukin-2 production
temperature homeostasis
signal transduction in absence of ligand
extrinsic apoptotic signaling pathway in absence of ligand
regulation of vascular endothelial growth factor production
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of signal transduction in absence of ligand
acute-phase response
response to copper ion
regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of mitotic nuclear division
regulation of interleukin-2 production
copper ion binding
positive regulation of nuclear division
positive regulation of cytokine biosynthetic process
cellular response to heat
acute inflammatory response
positive regulation of cell division
interleukin-1-mediated signaling pathway
extrinsic apoptotic signaling pathway
tissue remodeling
negative regulation of extrinsic apoptotic signaling pathway
regulation of cytokine biosynthetic process
response to heat
positive regulation of cytokine secretion
positive regulation of mitotic cell cycle
regulation of extrinsic apoptotic signaling pathway
positive regulation of angiogenesis