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Ask your administrator if you think this is wrong. ======= IL1B ======= == Gene Information == * **<color #00a2e8>Official Symbol</color>**: IL1B * **<color #00a2e8>Official Name</color>**: interleukin 1 beta * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3553|3553]] * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01584|P01584]] * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL1B&organism=9606|BioGRID]] * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL1B|Open PubMed]] * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147720|Open OMIM]] == Function Summary == * **<color #00a2e8>Entrez Summary</color>**: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]. * **<color #00a2e8>UniProt Summary</color>**: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. {ECO:0000269|PubMed:3920526}. <button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button> <button type='primary' size='sm' modal='GO_terms'>GO Terms</button> <modal id='Pfam_Domains' size='lg' title='Pfam Domains'> |IL1 propep| |IL1| </modal> <modal id='GO_terms' size='lg' title='GO Terms'> |regulation of myosin light chain kinase activity| |positive regulation of myosin light chain kinase activity| |positive regulation of calcidiol 1-monooxygenase activity| |monocyte aggregation| |positive regulation of vitamin D biosynthetic process| |fever generation| |positive regulation of cell adhesion molecule production| |smooth muscle adaptation| |negative regulation of adiponectin secretion| |positive regulation of complement activation| |positive regulation of vitamin metabolic process| |sequestering of triglyceride| |regulation of T-helper 1 cell cytokine production| |positive regulation of T-helper 1 cell cytokine production| |heat generation| |regulation of cell adhesion molecule production| |regulation of adiponectin secretion| |positive regulation of prostaglandin biosynthetic process| |hyaluronan biosynthetic process| |positive regulation of fever generation| |regulation of calcidiol 1-monooxygenase activity| |ectopic germ cell programmed cell death| |regulation of fever generation| |positive regulation of histone phosphorylation| |positive regulation of unsaturated fatty acid biosynthetic process| |regulation of prostaglandin biosynthetic process| |regulation of vitamin D biosynthetic process| |programmed cell death involved in cell development| |positive regulation of monocyte chemotactic protein-1 production| |leukocyte aggregation| |positive regulation of prostaglandin secretion| |regulation of unsaturated fatty acid biosynthetic process| |positive regulation of hormone biosynthetic process| |regulation of prostaglandin secretion| |positive regulation of heat generation| |interleukin-6 production| |positive regulation of chemokine biosynthetic process| |positive regulation of granulocyte macrophage colony-stimulating factor production| |regulation of vitamin metabolic process| |regulation of histone phosphorylation| |regulation of heat generation| |positive regulation of interleukin-2 biosynthetic process| |regulation of establishment of endothelial barrier| |regulation of endothelial cell development| |interleukin-1 receptor binding| |positive regulation of neuroinflammatory response| |positive regulation of hormone metabolic process| |positive regulation of glial cell proliferation| |interleukin-1 beta production| |positive regulation of membrane protein ectodomain proteolysis| |positive regulation of vascular endothelial growth factor receptor signaling pathway| |regulation of granulocyte macrophage colony-stimulating factor production| |positive regulation of interleukin-6 biosynthetic process| |regulation of chemokine biosynthetic process| |positive regulation of heterotypic cell-cell adhesion| |regulation of monocyte chemotactic protein-1 production| |positive regulation of icosanoid secretion| |interleukin-1 production| |positive regulation of humoral immune response| |negative regulation of glucose transmembrane transport| |positive regulation of steroid biosynthetic process| |positive regulation of fatty acid transport| |regulation of icosanoid secretion| |astrocyte activation| |regulation of interleukin-2 biosynthetic process| |positive regulation of fatty acid biosynthetic process| |positive regulation of T cell cytokine production| |positive regulation of T-helper 1 type immune response| |positive regulation of protein export from nucleus| |negative regulation of lipid catabolic process| |regulation of membrane protein ectodomain proteolysis| |regulation of interleukin-6 biosynthetic process| |positive regulation of lipid catabolic process| |positive regulation of alcohol biosynthetic process| |regulation of heterotypic cell-cell adhesion| |positive regulation of steroid metabolic process| |regulation of hormone biosynthetic process| |positive regulation of p38MAPK cascade| |regulation of T-helper 1 type immune response| |regulation of fatty acid transport| |positive regulation of monooxygenase activity| |positive regulation of vascular endothelial growth factor production| |lipid storage| |positive regulation of acute inflammatory response| |positive regulation of histone acetylation| |temperature homeostasis| |regulation of glial cell proliferation| |positive regulation of interleukin-2 production| |regulation of T cell cytokine production| |response to ATP| |extrinsic apoptotic signaling pathway in absence of ligand| |regulation of neuroinflammatory response| |hyaluronan metabolic process| |signal transduction in absence of ligand| |positive regulation of interleukin-6 secretion| |regulation of vascular endothelial growth factor receptor signaling pathway| |regulation of vascular endothelial growth factor production| |muscle adaptation| |positive regulation of peptidyl-lysine acetylation| |regulation of endothelial cell differentiation| |positive regulation of fatty acid metabolic process| |negative regulation of insulin receptor signaling pathway| |lipopolysaccharide-mediated signaling pathway| |positive regulation of organic acid transport| |negative regulation of signal transduction in absence of ligand| |negative regulation of extrinsic apoptotic signaling pathway in absence of ligand| |astrocyte development| |negative regulation of cellular response to insulin stimulus| |embryo implantation| |regulation of defense response to virus by host| |regulation of hormone metabolic process| |protein kinase B signaling| |glial cell activation| |regulation of protein export from nucleus| |positive regulation of nitric oxide biosynthetic process| |positive regulation of nitric oxide metabolic process| |acute-phase response| |regulation of p38MAPK cascade| |neuroinflammatory response| |positive regulation of protein acetylation| |regulation of endocrine process| |regulation of acute inflammatory response| |regulation of nitric-oxide synthase activity| |regulation of fatty acid biosynthetic process| |regulation of extrinsic apoptotic signaling pathway in absence of ligand| |positive regulation of epithelial to mesenchymal transition| |positive regulation of T cell mediated immunity| |positive regulation of interleukin-8 production| |leukocyte cell-cell adhesion| |positive regulation of anion transport| |positive regulation of reactive oxygen species biosynthetic process| |positive regulation of mitotic nuclear division| |astrocyte differentiation| |positive regulation of oxidoreductase activity| |regulation of interleukin-2 production| |regulation of monooxygenase activity| |positive regulation of cytokine production involved in immune response| |regulation of lipid catabolic process| |regulation of nitric oxide biosynthetic process| |regulation of histone acetylation| |positive regulation of chemokine production| |regulation of organic acid transport| |positive regulation of lipid transport| |negative regulation of synaptic transmission| |regulation of peptidyl-lysine acetylation| |positive regulation of nucleocytoplasmic transport| |negative regulation of hormone secretion| |regulation of insulin receptor signaling pathway| |positive regulation of interferon-gamma production| |positive regulation of nuclear division| |positive regulation of cytokine biosynthetic process| |positive regulation of phagocytosis| |positive regulation of gliogenesis| |regulation of interleukin-8 production| |regulation of T cell mediated immunity| |acute inflammatory response| |regulation of protein acetylation| |regulation of cellular response to insulin stimulus| |regulation of glucose transmembrane transport| |regulation of defense response to virus| |negative regulation of MAP kinase activity| |regulation of alcohol biosynthetic process| |positive regulation of NIK/NF-kappaB signaling| |regulation of chemokine production| |positive regulation of lipid biosynthetic process| |cellular response to mechanical stimulus| |positive regulation of lipid localization| |neutrophil chemotaxis| |negative regulation of lipid metabolic process| |regulation of epithelial to mesenchymal transition| |regulation of cytokine production involved in immune response| |regulation of reactive oxygen species biosynthetic process| |positive regulation of cell division| |regulation of fatty acid metabolic process| |secretory granule| |regulation of steroid biosynthetic process| |granulocyte chemotaxis| |positive regulation of histone modification| |neutrophil migration| |positive regulation of interleukin-6 production| |positive regulation of T cell proliferation| |regulation of anion transport| |positive regulation of reactive oxygen species metabolic process| |regulation of phagocytosis| |interleukin-1-mediated signaling pathway| |regulation of oxidoreductase activity| |extrinsic apoptotic signaling pathway| |positive regulation of production of molecular mediator of immune response| |regulation of interferon-gamma production| |granulocyte migration| |positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains| |negative regulation of extrinsic apoptotic signaling pathway| |glycosaminoglycan biosynthetic process| |positive regulation of chromatin organization| |positive regulation of lymphocyte mediated immunity| |positive regulation of adaptive immune response| |regulation of cytokine biosynthetic process| |regulation of nucleocytoplasmic transport| |mucopolysaccharide metabolic process| |glial cell development| |regulation of lipid transport| |aminoglycan biosynthetic process| |regulation of NIK/NF-kappaB signaling| |regulation of steroid metabolic process| |regulation of gliogenesis| |negative regulation of transmembrane transport| |regulation of complement activation| |myeloid leukocyte migration| |positive regulation of lymphocyte proliferation| |positive regulation of mononuclear cell proliferation| |integrin binding| |negative regulation of protein secretion| |positive regulation of leukocyte mediated immunity| |negative regulation of protein serine/threonine kinase activity| |response to organophosphorus| |regulation of humoral immune response| |positive regulation of leukocyte proliferation| |positive regulation of small molecule metabolic process| |regulation of lipid localization| |positive regulation of cytokine secretion| |positive regulation of JNK cascade| |negative regulation of peptide secretion| |positive regulation of inflammatory response| |regulation of interleukin-6 production| |regulation of production of molecular mediator of immune response| |regulation of epithelial cell differentiation| |positive regulation of lipid metabolic process| |regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains| |leukocyte chemotaxis| |regulation of histone modification| |cytokine production| |regulation of lymphocyte mediated immunity| |positive regulation of mitotic cell cycle| |positive regulation of NF-kappaB transcription factor activity| |response to purine-containing compound| |positive regulation of intracellular protein transport| |regulation of extrinsic apoptotic signaling pathway| |activation of MAPK activity| |glycosaminoglycan metabolic process| |regulation of T cell proliferation| |regulation of adaptive immune response| |positive regulation of angiogenesis| |maintenance of location| |aminoglycan metabolic process| |negative regulation of MAPK cascade| |positive regulation of stress-activated MAPK cascade| |regulation of cell division| |positive regulation of stress-activated protein kinase signaling cascade| |regulation of mitotic nuclear division| |glial cell differentiation| |response to carbohydrate| |regulation of cellular ketone metabolic process| |cytokine activity| |positive regulation of chromosome organization| |cellular response to interleukin-1| |regulation of insulin secretion| |regulation of reactive oxygen species metabolic process| |female pregnancy| |negative regulation of protein transport| |positive regulation of vasculature development| |positive regulation of I-kappaB kinase/NF-kappaB signaling| |cellular response to lipopolysaccharide| |negative regulation of establishment of protein localization| |regulation of JNK cascade| |regulation of lipid biosynthetic process| |regulation of chromatin organization| |cellular response to molecule of bacterial origin| |regulation of nuclear division| |response to interleukin-1| |positive regulation of T cell activation| |negative regulation of secretion by cell| |regulation of cytokine secretion| |regulation of leukocyte mediated immunity| |positive regulation of intracellular transport| |regulation of lymphocyte proliferation| |regulation of mononuclear cell proliferation| |cell chemotaxis| |regulation of peptide hormone secretion| |multi-multicellular organism process| |response to mechanical stimulus| |gliogenesis| |cellular response to biotic stimulus| |response to nutrient| |positive regulation of protein catabolic process| |positive regulation of leukocyte cell-cell adhesion| |positive regulation of immune effector process| |regulation of leukocyte proliferation| |negative regulation of apoptotic signaling pathway| |negative regulation of protein kinase activity| |regulation of intracellular protein transport| |negative regulation of secretion| |regulation of stress-activated MAPK cascade| |regulation of I-kappaB kinase/NF-kappaB signaling| |regulation of stress-activated protein kinase signaling cascade| |protein domain specific binding| |negative regulation of kinase activity| |lysosome| |positive regulation of cell-cell adhesion| |positive regulation of MAP kinase activity| |positive regulation of DNA-binding transcription factor activity| |regulation of hormone secretion| |positive regulation of protein secretion| |regulation of cellular response to growth factor stimulus| |positive regulation of ion transport| |negative regulation of transferase activity| |apoptotic signaling pathway| |positive regulation of cell cycle process| |regulation of angiogenesis| |positive regulation of peptide secretion| |negative regulation of neurogenesis| |regulation of ERK1 and ERK2 cascade| |regulation of leukocyte cell-cell adhesion| |muscle system process| |carboxylic acid biosynthetic process| |organic acid biosynthetic process| |negative regulation of catabolic process| |negative regulation of nervous system development| |cellular response to abiotic stimulus| |cellular response to environmental stimulus| |response to lipopolysaccharide| |regulation of T cell activation| |lipid localization| |regulation of vasculature development| |multicellular organismal homeostasis| |positive regulation of cellular protein localization| |response to molecule of bacterial origin| |activation of protein kinase activity| |negative regulation of cell development| |cellular response to external stimulus| |regulation of inflammatory response| |positive regulation of protein serine/threonine kinase activity| |regulation of MAP kinase activity| |regulation of chromosome organization| |regulation of intracellular transport| |regulation of neurotransmitter levels| |positive regulation of proteolysis| |positive regulation of lymphocyte activation| |positive regulation of cellular catabolic process| |MAPK cascade| |positive regulation of cell cycle| |leukocyte migration| |regulation of protein catabolic process| |signal transduction by protein phosphorylation| |regulation of lipid metabolic process| |regulation of apoptotic signaling pathway| |regulation of cell-cell adhesion| |positive regulation of secretion by cell| |positive regulation of cell adhesion| |positive regulation of leukocyte activation| |cellular response to drug| |negative regulation of protein phosphorylation| |positive regulation of cell activation| |positive regulation of protein transport| |regulation of DNA-binding transcription factor activity| |regulation of small molecule metabolic process| |positive regulation of catabolic process| |positive regulation of secretion| |modulation of chemical synaptic transmission| |regulation of trans-synaptic signaling| |negative regulation of phosphorylation| |positive regulation of cytokine production| |positive regulation of establishment of protein localization| |regulation of protein secretion| |regulation of immune effector process| |positive regulation of neurogenesis| |positive regulation of defense response| |negative regulation of transport| |regulation of peptide secretion| |response to nutrient levels| |inflammatory response| |positive regulation of cell migration| |cell-cell adhesion| |negative regulation of intracellular signal transduction| |regulation of lymphocyte activation| |regulation of protein serine/threonine kinase activity| |cellular response to lipid| |positive regulation of cell motility| |regulation of response to biotic stimulus| |response to extracellular stimulus| |regulation of hormone levels| |positive regulation of protein kinase activity| |positive regulation of nervous system development| |positive regulation of cellular component movement| |regulation of cellular protein localization| |cellular response to organic cyclic compound| |positive regulation of cell development| |positive regulation of MAPK cascade| |chemotaxis| |regulation of vesicle-mediated transport| |positive regulation of locomotion| |taxis| |negative regulation of phosphate metabolic process| |negative regulation of phosphorus metabolic process| |regulation of transmembrane transport| |positive regulation of kinase activity| |regulation of system process| |small molecule biosynthetic process| |negative regulation of protein modification process| |regulation of leukocyte activation| |positive regulation of response to external stimulus| |carbohydrate derivative biosynthetic process| |positive regulation of organelle organization| |regulation of mitotic cell cycle| |regulation of cell activation| |positive regulation of transferase activity| |developmental process involved in reproduction| |cytokine-mediated signaling pathway| |negative regulation of cell population proliferation| |regulation of cell adhesion| |response to bacterium| |regulation of cytokine production| |regulation of ion transport| |regulation of protein transport| |negative regulation of cell differentiation| |regulation of proteolysis| |regulation of cellular response to stress| |regulation of peptide transport| |regulation of establishment of protein localization| |regulation of secretion by cell| |regulation of MAPK cascade| |regulation of cell cycle process| |regulation of defense response| |regulation of multi-organism process| |negative regulation of catalytic activity| |regulation of protein kinase activity| |regulation of secretion| |regulation of neurogenesis| |regulation of cellular catabolic process| |regulation of cell migration| |response to lipid| |positive regulation of immune response| |regulation of kinase activity| |negative regulation of apoptotic process| |negative regulation of programmed cell death| |carboxylic acid metabolic process| |regulation of cell motility| |positive regulation of cell population proliferation| |regulation of cellular localization| |response to organic cyclic compound| |apoptotic process| |regulation of nervous system development| |cell adhesion| |regulation of cell development| |biological adhesion| |negative regulation of developmental process| |cell migration| |positive regulation of cell differentiation| |protein phosphorylation| |regulation of transferase activity| |central nervous system development| |regulation of locomotion| |positive regulation of transport| |regulation of catabolic process| |negative regulation of cell death| |multi-organism reproductive process| |regulation of cellular component movement| |response to organonitrogen compound| |oxoacid metabolic process| |cellular response to cytokine stimulus| |positive regulation of protein phosphorylation| |positive regulation of intracellular signal transduction| |response to drug| |organic acid metabolic process| |regulation of protein localization| |carbohydrate derivative metabolic process| |negative regulation of cellular protein metabolic process| |programmed cell death| |cellular response to oxygen-containing compound| |positive regulation of phosphorylation| |regulation of anatomical structure morphogenesis| |cell activation| |cell motility| |localization of cell| |response to nitrogen compound| |cell death| |regulation of response to external stimulus| |response to cytokine| |negative regulation of protein metabolic process| |cell-cell signaling| |positive regulation of phosphorus metabolic process| |positive regulation of phosphate metabolic process| |negative regulation of molecular function| |regulation of immune response| |positive regulation of immune system process| |response to abiotic stimulus| |regulation of cell cycle| |negative regulation of multicellular organismal process| |positive regulation of cellular component organization| |positive regulation of transcription by RNA polymerase II| |positive regulation of protein modification process| |negative regulation of signal transduction| |phosphorylation| |regulation of organelle organization| |response to other organism| |response to external biotic stimulus| |locomotion| |response to biotic stimulus| |defense response| |negative regulation of cell communication| |negative regulation of signaling| |positive regulation of developmental process| |organonitrogen compound biosynthetic process| |reproductive process| |reproduction| |positive regulation of catalytic activity| |regulation of protein phosphorylation| |regulation of response to stress| |generation of neurons| |positive regulation of transcription, DNA-templated| |regulation of apoptotic process| |movement of cell or subcellular component| |response to oxygen-containing compound| |regulation of programmed cell death| |regulation of phosphorylation| |extracellular space| |positive regulation of cellular protein metabolic process| |regulation of cell population proliferation| |negative regulation of response to stimulus| |neurogenesis| |positive regulation of nucleic acid-templated transcription| |positive regulation of RNA biosynthetic process| |homeostatic process| |cell development| |regulation of immune system process| |positive regulation of signal transduction| |regulation of cell death| |intracellular signal transduction| |positive regulation of protein metabolic process| |positive regulation of RNA metabolic process| |positive regulation of multicellular organismal process| |small molecule metabolic process| |macromolecule biosynthetic process| |positive regulation of molecular function| |regulation of phosphate metabolic process| |regulation of phosphorus metabolic process| |regulation of cell differentiation| |positive regulation of cell communication| |positive regulation of signaling| |regulation of intracellular signal transduction| |regulation of protein modification process| |regulation of transport| |immune response| |positive regulation of nucleobase-containing compound metabolic process| |positive regulation of macromolecule biosynthetic process| |extracellular region| |system process| |positive regulation of cellular biosynthetic process| |positive regulation of gene expression| |positive regulation of biosynthetic process| </modal> \\ === CRISPR Data === <button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button> <button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button> <button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button> <modal id='Compound_Hit' size='lg' title='Compound Hit'> ^Screen^Score^ |[[:results:exp211|AICAR 240μM R05 exp211]]|1.82| |[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.11| </modal> <modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'> ^Gene^Correlation^ |[[:human genes:v:vasn|VASN]]|0.405| </modal> <modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'> Global Fraction of Cell Lines Where Essential: 0/726 ^Tissue^Fraction Of Cell Lines Where Essential^ |1290807.0|0/1| |909776.0|0/1| |bile duct|0/28| |blood|0/28| |bone|0/25| |breast|0/33| |central nervous system|0/56| |cervix|0/4| |colorectal|0/17| |esophagus|0/13| |fibroblast|0/1| |gastric|0/15| |kidney|0/21| |liver|0/20| |lung|0/75| |lymphocyte|0/14| |ovary|0/26| |pancreas|0/24| |peripheral nervous system|0/16| |plasma cell|0/15| |prostate|0/1| |skin|0/24| |soft tissue|0/7| |thyroid|0/2| |upper aerodigestive|0/22| |urinary tract|0/29| |uterus|0/5| </modal> == Essentiality in NALM6 == * **<color #00a2e8>Essentiality Rank</color>**: 14184 * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.81 <button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button> <modal id='Dist_expr' size='lg' title='IL1B Expression in NALM6 Cells: -0.81'> {{:chemogenomics:nalm6 dist.png?nolink |}} </modal> Last modified: 2026/01/07 22:36by 127.0.0.1