IL1R1

Gene Information

Official Symbol: IL1R1
Official Name: interleukin 1 receptor type 1
Aliases and Previous Symbols: N/A
Entrez ID: 3554
UniProt: P14778
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. {ECO:0000269|PubMed:10671496}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13321
Expression level (log2 read counts): 1.16

Expression Distribution

I-set
TIR

positive regulation of interleukin-1-mediated signaling pathway
interleukin-1, type I, activating receptor activity
regulation of T-helper 1 cell cytokine production
positive regulation of T-helper 1 cell cytokine production
positive regulation of neutrophil extravasation
regulation of interleukin-1-mediated signaling pathway
interleukin-1 receptor activity
interleukin-1 binding
regulation of neutrophil extravasation
platelet-derived growth factor receptor binding
positive regulation of cellular extravasation
positive regulation of T cell cytokine production
positive regulation of T-helper 1 type immune response
regulation of T-helper 1 type immune response
regulation of cellular extravasation
positive regulation of neutrophil migration
regulation of T cell cytokine production
regulation of neutrophil migration
positive regulation of T cell mediated immunity
positive regulation of cytokine-mediated signaling pathway
positive regulation of cytokine production involved in immune response
positive regulation of response to cytokine stimulus
positive regulation of interferon-gamma production
regulation of T cell mediated immunity
regulation of cytokine production involved in immune response
interleukin-1-mediated signaling pathway
positive regulation of production of molecular mediator of immune response
regulation of interferon-gamma production
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
protease binding
positive regulation of adaptive immune response
positive regulation of lymphocyte mediated immunity
positive regulation of leukocyte migration
positive regulation of leukocyte mediated immunity
transmembrane signaling receptor activity
regulation of production of molecular mediator of immune response
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of lymphocyte mediated immunity
regulation of adaptive immune response
regulation of cytokine-mediated signaling pathway