IL1RL1

Gene Information

Official Symbol: IL1RL1
Official Name: interleukin 1 receptor like 1
Aliases and Previous Symbols: N/A
Entrez ID: 9173
UniProt: Q01638
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. {ECO:0000269|PubMed:16286016, ECO:0000305|PubMed:19836339}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17761
Expression level (log2 read counts): 0.87

Expression Distribution

Screen	Score
CI-1040 9.5μM R08 exp472	-1.77
Salinomycin 3.5μM R08 exp521	-1.7
Trichostatin-A 0.06μM R07 exp415	1.82

I-set
TIR

interleukin-33 binding
interleukin-33 receptor activity
interleukin-33-mediated signaling pathway
interleukin-1 receptor activity
negative regulation of T-helper 1 type immune response
positive regulation of interleukin-5 production
positive regulation of chemokine secretion
regulation of chemokine secretion
regulation of interleukin-5 production
positive regulation of macrophage activation
regulation of T-helper 1 type immune response
negative regulation of interferon-gamma production
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
negative regulation of adaptive immune response
cytokine receptor activity
regulation of macrophage activation
positive regulation of chemokine production
regulation of chemokine production
regulation of interferon-gamma production
positive regulation of cytokine secretion
positive regulation of inflammatory response
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
negative regulation of immune response
regulation of adaptive immune response
regulation of cytokine secretion
positive regulation of protein secretion
negative regulation of cytokine production
positive regulation of peptide secretion
regulation of inflammatory response
external side of plasma membrane
positive regulation of secretion by cell
positive regulation of leukocyte activation
positive regulation of cell activation
positive regulation of protein transport
positive regulation of secretion
negative regulation of immune system process
positive regulation of cytokine production
positive regulation of establishment of protein localization
regulation of protein secretion
positive regulation of defense response