IL24

Entrez Summary: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
UniProt Summary: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Lapatinib 5μM R01 exp47	-1.89
Aminopterin 0.005μM R07 exp335	1.94

serine phosphorylation of STAT protein
cellular response to interleukin-4
response to interleukin-4
positive regulation of tyrosine phosphorylation of STAT protein
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
cytokine activity
peptidyl-serine phosphorylation
cellular response to lipopolysaccharide
positive regulation of peptidyl-tyrosine phosphorylation
cellular response to molecule of bacterial origin
peptidyl-serine modification
cellular response to biotic stimulus
regulation of peptidyl-tyrosine phosphorylation
negative regulation of cell migration
negative regulation of cell motility
negative regulation of cellular component movement
response to lipopolysaccharide
negative regulation of locomotion
response to molecule of bacterial origin
wound healing
cellular response to lipid
response to wounding
cytokine-mediated signaling pathway
negative regulation of cell population proliferation
response to bacterium
regulation of cell migration
response to lipid
peptidyl-amino acid modification
regulation of cell motility
positive regulation of cell population proliferation
apoptotic process
protein phosphorylation
regulation of locomotion
regulation of cellular component movement
cellular response to cytokine stimulus
positive regulation of protein phosphorylation