IL2 [The Human Chemical-Genetic Interaction Map Project]

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======= IL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL2
  * **<color #00a2e8>Official Name</color>**: interleukin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3558|3558]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60568|P60568]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147680|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kappa-type opioid receptor binding|
|regulation of T cell homeostatic proliferation|
|interleukin-2 receptor binding|
|glycosphingolipid binding|
|kinase activator activity|
|negative regulation of T-helper 17 cell differentiation|
|negative regulation of T-helper 17 type immune response|
|positive regulation of isotype switching to IgG isotypes|
|negative regulation of B cell apoptotic process|
|interleukin-2-mediated signaling pathway|
|regulation of isotype switching to IgG isotypes|
|cellular response to interleukin-2|
|positive regulation of immunoglobulin secretion|
|response to interleukin-2|
|positive regulation of regulatory T cell differentiation|
|negative regulation of T-helper cell differentiation|
|regulation of T-helper 17 cell differentiation|
|regulation of B cell apoptotic process|
|positive regulation of interleukin-17 production|
|regulation of immunoglobulin secretion|
|regulation of T-helper 17 type immune response|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of activated T cell proliferation|
|negative regulation of alpha-beta T cell differentiation|
|negative regulation of heart contraction|
|positive regulation of isotype switching|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|negative regulation of lymphocyte apoptotic process|
|regulation of interleukin-17 production|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of regulatory T cell differentiation|
|signal transduction in absence of ligand|
|positive regulation of tissue remodeling|
|extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of blood circulation|
|regulation of isotype switching|
|regulation of T-helper cell differentiation|
|regulation of activated T cell proliferation|
|positive regulation of B cell mediated immunity|
|positive regulation of immunoglobulin mediated immune response|
|negative regulation of alpha-beta T cell activation|
|positive regulation of DNA recombination|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of B cell proliferation|
|positive regulation of immunoglobulin production|
|negative regulation of T cell differentiation|
|positive regulation of dendritic spine development|
|negative regulation of adaptive immune response|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|negative regulation of leukocyte apoptotic process|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|regulation of lymphocyte apoptotic process|
|negative regulation of lymphocyte differentiation|
|natural killer cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of B cell proliferation|
|regulation of alpha-beta T cell differentiation|
|regulation of immunoglobulin production|
|positive regulation of interferon-gamma production|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of dendritic spine development|
|regulation of tissue remodeling|
|positive regulation of dendrite development|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of leukocyte proliferation|
|regulation of tyrosine phosphorylation of STAT protein|
|cell|
|regulation of leukocyte apoptotic process|
|positive regulation of T cell differentiation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of receptor signaling pathway via STAT|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of T cell proliferation|
|extrinsic apoptotic signaling pathway|
|positive regulation of production of molecular mediator of immune response|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of leukocyte differentiation|
|regulation of DNA recombination|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|negative regulation of T cell activation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|response to ethanol|
|positive regulation of lymphocyte proliferation|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|regulation of receptor signaling pathway via STAT|
|T cell differentiation|
|negative regulation of hemopoiesis|
|negative regulation of inflammatory response|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|positive regulation of inflammatory response|
|regulation of production of molecular mediator of immune response|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|regulation of dendrite development|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|growth factor activity|
|positive regulation of cell growth|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|cytokine activity|
|carbohydrate binding|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of DNA metabolic process|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|response to alcohol|
|T cell activation|
|lymphocyte differentiation|
|regulation of heart contraction|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|positive regulation of growth|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|apoptotic signaling pathway|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|response to antibiotic|
|regulation of T cell activation|
|regulation of cytosolic calcium ion concentration|
|leukocyte differentiation|
|regulation of inflammatory response|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|MAPK cascade|
|positive regulation of cell projection organization|
|lymphocyte activation|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|negative regulation of protein phosphorylation|
|positive regulation of cell activation|
|regulation of cell growth|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|response to toxic substance|
|regulation of lymphocyte activation|
|positive regulation of nervous system development|
|positive regulation of cell development|
|hemopoiesis|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|regulation of system process|
|negative regulation of protein modification process|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|immune system development|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|regulation of growth|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|regulation of protein transport|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|ion homeostasis|
|regulation of secretion|
|regulation of neurogenesis|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of transport|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14130
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>