IL2RA

Gene Information

Official Symbol: IL2RA
Official Name: interleukin 2 receptor subunit alpha
Aliases and Previous Symbols: N/A
Entrez ID: 3559
UniProt: P01589
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009].
UniProt Summary: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. {ECO:0000269|PubMed:23416241, ECO:0000269|PubMed:24116927}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4485
Expression level (log2 read counts): 1.06

Expression Distribution

interleukin-2 receptor complex
interleukin-2 receptor activity
interleukin-2 binding
regulation of T cell homeostatic proliferation
activation-induced cell death of T cells
regulation of T cell tolerance induction
interleukin-2-mediated signaling pathway
cellular response to interleukin-2
response to interleukin-2
T cell apoptotic process
regulation of tolerance induction
lymphocyte apoptotic process
positive regulation of activated T cell proliferation
negative regulation of defense response to virus
leukocyte apoptotic process
inflammatory response to antigenic stimulus
regulation of regulatory T cell differentiation
T cell homeostasis
regulation of activated T cell proliferation
lymphocyte homeostasis
negative regulation of T cell proliferation
leukocyte homeostasis
regulation of defense response to virus
negative regulation of mononuclear cell proliferation
negative regulation of lymphocyte proliferation
negative regulation of leukocyte proliferation
positive regulation of T cell differentiation
negative regulation of response to biotic stimulus
positive regulation of lymphocyte differentiation
positive regulation of T cell proliferation
negative regulation of T cell activation
negative regulation of immune effector process
negative regulation of leukocyte cell-cell adhesion
Notch signaling pathway
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
negative regulation of inflammatory response
regulation of T cell differentiation
negative regulation of lymphocyte activation