IL2RG

Entrez Summary: The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010].
UniProt Summary: Common subunit for the receptors for a variety of interleukins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Nifurtimox 1μM R03 exp141	-1.78
Q15 1 to 2μM on day4 R04 exp164	-1.71

EpoR lig-bind
IL6Ra-bind

interleukin-4 receptor activity
interleukin-7 receptor activity
interleukin-2 binding
interleukin-2 receptor activity
interleukin-15 receptor activity
interleukin-4-mediated signaling pathway
response to interleukin-21
interleukin-21-mediated signaling pathway
cellular response to interleukin-21
cellular response to interleukin-9
interleukin-9-mediated signaling pathway
response to interleukin-9
interleukin-2-mediated signaling pathway
cellular response to interleukin-2
cellular response to interleukin-15
response to interleukin-2
interleukin-15-mediated signaling pathway
response to interleukin-15
interleukin-7-mediated signaling pathway
cellular response to interleukin-7
response to interleukin-7
cellular response to interleukin-4
response to interleukin-4
cytokine binding
cytokine receptor activity
positive regulation of phagocytosis
regulation of phagocytosis
receptor complex
endosome
MAPK cascade
signal transduction by protein phosphorylation
external side of plasma membrane
regulation of vesicle-mediated transport
cell surface
cytokine-mediated signaling pathway
viral process
symbiotic process
interspecies interaction between organisms
protein phosphorylation
positive regulation of transport