IL34

Entrez Summary: N/A
UniProt Summary: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. {ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

macrophage colony-stimulating factor receptor binding
macrophage proliferation
microglial cell proliferation
positive regulation of monocyte differentiation
positive regulation of macrophage differentiation
glial cell proliferation
regulation of monocyte differentiation
regulation of macrophage differentiation
positive regulation of oligodendrocyte differentiation
regulation of oligodendrocyte differentiation
positive regulation of glial cell differentiation
positive regulation of myeloid leukocyte differentiation
regulation of glial cell differentiation
positive regulation of gliogenesis
positive regulation of myeloid cell differentiation
leukocyte proliferation
regulation of gliogenesis
regulation of myeloid leukocyte differentiation
positive regulation of leukocyte differentiation
growth factor activity
cytokine activity
positive regulation of hemopoiesis
gliogenesis
regulation of myeloid cell differentiation
regulation of leukocyte differentiation
regulation of hemopoiesis
positive regulation of neurogenesis
inflammatory response
positive regulation of nervous system development
positive regulation of cell development
cell population proliferation
cytokine-mediated signaling pathway
innate immune response
regulation of neurogenesis
positive regulation of cell population proliferation
regulation of nervous system development
regulation of cell development
defense response to other organism
positive regulation of cell differentiation
cellular response to cytokine stimulus