IL4I1

Entrez Summary: This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
UniProt Summary: Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Dynasore 7μM R08 exp436	-1.82
Disulfiram 4.3μM R06 exp281	2.28

L-amino-acid oxidase activity
erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
L-phenylalanine catabolic process
L-phenylalanine metabolic process
erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
aromatic amino acid family catabolic process
aromatic amino acid family metabolic process
alpha-amino acid catabolic process
oxidoreductase activity
cellular amino acid catabolic process
drug catabolic process
alpha-amino acid metabolic process
lysosome
organic acid catabolic process
carboxylic acid catabolic process
cellular amino acid metabolic process
small molecule catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
drug metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
extracellular region