IL6R

Gene Information

Official Symbol: IL6R
Official Name: interleukin 6 receptor
Aliases and Previous Symbols: N/A
Entrez ID: 3570
UniProt: P08887
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011].
UniProt Summary: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4437
Expression level (log2 read counts): 2.02

Expression Distribution

ciliary neurotrophic factor binding
interleukin-6 receptor activity
interleukin-12 alpha subunit binding
interleukin-6 binding
hepatic immune response
interleukin-23 receptor binding
interleukin-6 receptor complex
interleukin-12 complex
interleukin-23 complex
ciliary neurotrophic factor receptor complex
ciliary neurotrophic factor receptor activity
interleukin-12 receptor binding
positive regulation of glomerular mesangial cell proliferation
ciliary neurotrophic factor-mediated signaling pathway
interleukin-6 receptor binding
positive regulation of activation of Janus kinase activity
positive regulation of NK T cell activation
positive regulation of cell proliferation involved in kidney development
regulation of activation of Janus kinase activity
regulation of NK T cell activation
regulation of glomerular mesangial cell proliferation
positive regulation of glomerulus development
regulation of cell proliferation involved in kidney development
regulation of glomerulus development
interleukin-6-mediated signaling pathway
positive regulation of T-helper 1 type immune response
positive regulation of natural killer cell activation
positive regulation of activated T cell proliferation
regulation of T-helper 1 type immune response
cellular response to interleukin-6
organ or tissue specific immune response
regulation of natural killer cell activation
response to interleukin-6
regulation of activated T cell proliferation
endocrine pancreas development
acute-phase response
cytokine binding
positive regulation of kidney development
monocyte chemotaxis
cytokine receptor activity