IL7 [The Human Chemical-Genetic Interaction Map Project]

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======= IL7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL7
  * **<color #00a2e8>Official Name</color>**: interleukin 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3574|3574]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13232|P13232]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-7 receptor binding|
|positive regulation of B cell differentiation|
|interleukin-7-mediated signaling pathway|
|T cell lineage commitment|
|bone resorption|
|regulation of B cell differentiation|
|response to interleukin-7|
|cellular response to interleukin-7|
|homeostasis of number of cells within a tissue|
|negative regulation of signal transduction in absence of ligand|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|positive regulation of B cell proliferation|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|bone remodeling|
|positive regulation of organ growth|
|positive regulation of cytokine-mediated signaling pathway|
|positive regulation of chemokine production|
|positive regulation of response to cytokine stimulus|
|regulation of B cell proliferation|
|regulation of chemokine production|
|positive regulation of T cell differentiation|
|regulation of organ growth|
|positive regulation of lymphocyte differentiation|
|tissue remodeling|
|negative regulation of extrinsic apoptotic signaling pathway|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|T cell differentiation|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|positive regulation of leukocyte differentiation|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|growth factor activity|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|positive regulation of developmental growth|
|cytokine activity|
|regulation of response to cytokine stimulus|
|positive regulation of hemopoiesis|
|tissue homeostasis|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|negative regulation of apoptotic signaling pathway|
|T cell activation|
|lymphocyte differentiation|
|cell fate commitment|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|positive regulation of growth|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|regulation of developmental growth|
|leukocyte differentiation|
|anatomical structure homeostasis|
|humoral immune response|
|positive regulation of lymphocyte activation|
|collagen-containing extracellular matrix|
|lymphocyte activation|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of lymphocyte activation|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|regulation of growth|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|negative regulation of catalytic activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|leukocyte activation|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|cell activation|
|response to cytokine|
|cell-cell signaling|
|negative regulation of molecular function|
|positive regulation of immune system process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|immune response|
|extracellular region|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18071
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL7 Expression in NALM6 Cells: -1.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>