IL7

Gene Information

Official Symbol: IL7
Official Name: interleukin 7
Aliases and Previous Symbols: N/A
Entrez ID: 3574
UniProt: P13232
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18071
Expression level (log2 read counts): -1.82

Expression Distribution

interleukin-7 receptor binding
positive regulation of B cell differentiation
interleukin-7-mediated signaling pathway
T cell lineage commitment
bone resorption
regulation of B cell differentiation
response to interleukin-7
cellular response to interleukin-7
homeostasis of number of cells within a tissue
negative regulation of signal transduction in absence of ligand
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of B cell proliferation
regulation of extrinsic apoptotic signaling pathway in absence of ligand
bone remodeling
positive regulation of organ growth
positive regulation of cytokine-mediated signaling pathway
positive regulation of chemokine production
positive regulation of response to cytokine stimulus
regulation of B cell proliferation
regulation of chemokine production
positive regulation of T cell differentiation
regulation of organ growth
positive regulation of lymphocyte differentiation
tissue remodeling
negative regulation of extrinsic apoptotic signaling pathway
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
T cell differentiation
positive regulation of leukocyte proliferation
regulation of T cell differentiation
positive regulation of leukocyte differentiation
regulation of extrinsic apoptotic signaling pathway
regulation of cytokine-mediated signaling pathway
growth factor activity
positive regulation of B cell activation
regulation of lymphocyte differentiation
positive regulation of developmental growth
cytokine activity
regulation of response to cytokine stimulus
positive regulation of hemopoiesis