IL7R

Gene Information

Official Symbol: IL7R
Official Name: interleukin 7 receptor
Aliases and Previous Symbols: N/A
Entrez ID: 3575
UniProt: P16871
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14844
Expression level (log2 read counts): 9.39

Expression Distribution

Screen	Score
JQ1 0.8μM R08 exp435	-1.71
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.79

interleukin-7 receptor activity
negative regulation of T cell mediated cytotoxicity
positive regulation of T cell differentiation in thymus
lymph node development
negative regulation of leukocyte mediated cytotoxicity
negative regulation of T cell apoptotic process
negative regulation of T cell mediated immunity
interleukin-7-mediated signaling pathway
negative regulation of cell killing
regulation of T cell differentiation in thymus
negative regulation of lymphocyte apoptotic process
cellular response to interleukin-7
response to interleukin-7
regulation of T cell apoptotic process
regulation of T cell mediated cytotoxicity
negative regulation of lymphocyte mediated immunity
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
B cell proliferation
negative regulation of adaptive immune response
negative regulation of leukocyte apoptotic process
cytokine receptor activity
negative regulation of leukocyte mediated immunity
regulation of lymphocyte apoptotic process
clathrin-coated vesicle membrane
regulation of T cell mediated immunity
regulation of leukocyte mediated cytotoxicity
regulation of leukocyte apoptotic process
positive regulation of T cell differentiation
lymphocyte proliferation
mononuclear cell proliferation
positive regulation of receptor signaling pathway via STAT
positive regulation of lymphocyte differentiation
leukocyte proliferation
regulation of cell killing
regulation of DNA recombination
negative regulation of immune effector process
regulation of receptor signaling pathway via STAT
T cell differentiation
regulation of T cell differentiation
antigen binding