IMP3 [The Human Chemical-Genetic Interaction Map Project]

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======= IMP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IMP3
  * **<color #00a2e8>Official Name</color>**: IMP U3 small nucleolar ribonucleoprotein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55272|55272]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NV31|Q9NV31]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IMP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IMP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. {ECO:0000269|PubMed:12655004}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|S4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|preribosome|
|Mpp10 complex|
|snoRNA binding|
|rRNA binding|
|small-subunit processome|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.71|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.76|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.83|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.84|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.93|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.511|
|[[:human genes:r:rpl35|RPL35]]|0.433|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 679/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|28/28|
|bone|25/26|
|breast|29/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|18/21|
|liver|17/20|
|lung|70/75|
|lymphocyte|14/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1028
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IMP3 Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>