IMP3

Entrez Summary: N/A
UniProt Summary: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. {ECO:0000269|PubMed:12655004}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 679/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	28/28
bone	25/26
breast	29/33
central nervous system	53/56
cervix	4/4
colorectal	14/17
esophagus	13/13
fibroblast	1/1
gastric	14/16
kidney	18/21
liver	17/20
lung	70/75
lymphocyte	14/16
ovary	25/26
pancreas	23/24
peripheral nervous system	14/16
plasma cell	14/15
prostate	0/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	27/29
uterus	4/5

Expression Distribution

preribosome
Mpp10 complex
snoRNA binding
rRNA binding
small-subunit processome
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
gene expression