IMPDH1

Gene Information

Official Symbol: IMPDH1
Official Name: inosine monophosphate dehydrogenase 1
Aliases and Previous Symbols: N/A
Entrez ID: 3614
UniProt: P20839
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8850
Expression level (log2 read counts): 6.73

Expression Distribution

NMO
FMN dh
IMPDH
CBS

IMP dehydrogenase activity
GMP biosynthetic process
GTP biosynthetic process
guanosine-containing compound biosynthetic process
GMP metabolic process
purine ribonucleoside monophosphate biosynthetic process
purine nucleoside monophosphate biosynthetic process
purine ribonucleoside biosynthetic process
ribonucleoside biosynthetic process
purine nucleoside biosynthetic process
GTP metabolic process
ribonucleoside monophosphate biosynthetic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
nucleoside biosynthetic process
guanosine-containing compound metabolic process
glycosyl compound biosynthetic process
nucleoside monophosphate biosynthetic process
purine ribonucleoside triphosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
ribonucleoside triphosphate biosynthetic process
ribonucleoside monophosphate metabolic process
purine ribonucleoside triphosphate metabolic process
purine ribonucleoside metabolic process
nucleotide binding
nucleoside triphosphate biosynthetic process
purine nucleoside metabolic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
nucleoside monophosphate metabolic process
ribonucleoside metabolic process
lymphocyte proliferation
mononuclear cell proliferation
azurophil granule lumen
nucleoside triphosphate metabolic process
leukocyte proliferation
nucleobase-containing small molecule biosynthetic process
nucleoside metabolic process
secretory granule lumen
ficolin-1-rich granule lumen