INCA1

Gene Information

Official Symbol: INCA1
Official Name: inhibitor of CDK, cyclin A1 interacting protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 388324
UniProt: Q0VD86
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3579
Expression level (log2 read counts): 1.99

Expression Distribution

cyclin-dependent protein serine/threonine kinase inhibitor activity
negative regulation of cyclin-dependent protein serine/threonine kinase activity
cyclin binding
negative regulation of cyclin-dependent protein kinase activity
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
negative regulation of protein serine/threonine kinase activity
positive regulation of apoptotic signaling pathway
negative regulation of protein kinase activity
negative regulation of kinase activity
protein-containing complex binding
negative regulation of transferase activity
nuclear body
regulation of apoptotic signaling pathway
negative regulation of protein phosphorylation
negative regulation of phosphorylation
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of cell cycle
negative regulation of protein modification process
positive regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of cell population proliferation
positive regulation of cell death
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of cell cycle
regulation of protein phosphorylation
regulation of apoptotic process
regulation of programmed cell death
regulation of phosphorylation
regulation of cell population proliferation
positive regulation of signal transduction
regulation of cell death