ING2 [The Human Chemical-Genetic Interaction Map Project]

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======= ING2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ING2
  * **<color #00a2e8>Official Name</color>**: inhibitor of growth family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3622|3622]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H160|Q9H160]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ING2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ING2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604215|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). {ECO:0000269|PubMed:11481424, ECO:0000269|PubMed:12859901}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ING|
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|germ-line stem cell division|
|male germ-line stem cell asymmetric division|
|CCAAT-binding factor complex|
|germline stem cell asymmetric division|
|asymmetric stem cell division|
|seminiferous tubule development|
|Sin3 complex|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|asymmetric cell division|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|positive regulation of histone deacetylation|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|positive regulation of protein deacetylation|
|male meiosis I|
|regulation of histone deacetylation|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|negative regulation of signal transduction by p53 class mediator|
|stem cell division|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of cellular senescence|
|regulation of protein deacetylation|
|regulation of cell aging|
|male meiotic nuclear division|
|methylated histone binding|
|sperm motility|
|flagellated sperm motility|
|negative regulation of response to DNA damage stimulus|
|phosphatidylinositol binding|
|positive regulation of histone modification|
|cilium-dependent cell motility|
|cilium or flagellum-dependent cell motility|
|negative regulation of intrinsic apoptotic signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of chromatin organization|
|meiosis I|
|meiosis I cell cycle process|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|male gonad development|
|development of primary male sexual characteristics|
|regulation of histone modification|
|spermatid development|
|meiotic nuclear division|
|spermatid differentiation|
|male sex differentiation|
|regulation of intrinsic apoptotic signaling pathway|
|meiotic cell cycle process|
|positive regulation of chromosome organization|
|regulation of signal transduction by p53 class mediator|
|regulation of chromatin organization|
|gonad development|
|development of primary sexual characteristics|
|regulation of response to DNA damage stimulus|
|meiotic cell cycle|
|negative regulation of apoptotic signaling pathway|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|germ cell development|
|sex differentiation|
|protein-containing complex binding|
|regulation of cellular response to growth factor stimulus|
|nuclear division|
|organelle fission|
|regulation of chromosome organization|
|cellular process involved in reproduction in multicellular organism|
|chromatin binding|
|regulation of apoptotic signaling pathway|
|reproductive structure development|
|reproductive system development|
|cell division|
|negative regulation of intracellular signal transduction|
|spermatogenesis|
|male gamete generation|
|positive regulation of organelle organization|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|gamete generation|
|chromatin organization|
|regulation of cellular response to stress|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|Golgi apparatus|
|multi-organism reproductive process|
|negative regulation of cell death|
|cell cycle process|
|chromosome organization|
|cell motility|
|localization of cell|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|DNA binding|
|regulation of response to stress|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.71|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.77|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.09|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ing1|ING1]]|0.514|
|[[:human genes:p:prim1|PRIM1]]|0.452|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18933
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ING2 Expression in NALM6 Cells: 3.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>