ING4

Entrez Summary: This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.79
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.9
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.98

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ING
PHD

histone H4-K12 acetylation
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
DNA damage response, signal transduction resulting in transcription
histone H4-K8 acetylation
histone H4-K5 acetylation
histone H4-K16 acetylation
histone acetyltransferase complex
intermediate filament cytoskeleton
histone H3 acetylation
histone H4 acetylation
methylated histone binding
DNA damage response, signal transduction by p53 class mediator
signal transduction in response to DNA damage
histone acetylation
internal peptidyl-lysine acetylation
signal transduction by p53 class mediator
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
cell cycle arrest
protein acylation
DNA replication
negative regulation of growth
transcription coactivator activity
peptidyl-lysine modification
histone modification
covalent chromatin modification
negative regulation of cell cycle
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of growth
negative regulation of cell population proliferation
positive regulation of cell death
chromatin organization
cellular response to DNA damage stimulus
peptidyl-amino acid modification
apoptotic process
cell cycle process
programmed cell death
chromosome organization