INO80D [The Human Chemical-Genetic Interaction Map Project]

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======= INO80D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INO80D
  * **<color #00a2e8>Official Name</color>**: INO80 complex subunit D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54891|54891]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53TQ3|Q53TQ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INO80D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INO80D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619207|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA recombination|
|protein deubiquitination|
|protein modification by small protein removal|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|protein modification by small protein conjugation or removal|
|proteolysis|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.24|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.24|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.91|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.9|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.86|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.75|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.71|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.7|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.71|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.72|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.83|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.88|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.93|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.05|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9430
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INO80D Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>