INO80D

Entrez Summary: N/A
UniProt Summary: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Artemisinin 50μM R08 exp450	-2.24
Trimetrexate 0.03μM R08 exp535	-2.24
JQ1 0.8μM R08 exp435	-1.91
Thioridazine 5μM R08 exp530	-1.9
Trientine 500μM R08 exp534	-1.86
Trametinib 10μM R02 exp83	-1.75
Aphidicolin 0.4μM R08 exp440	-1.71
Apcin 50 to 100μM on day4 R04 exp176	1.7
Salubrinal 20μM R07 exp399	1.71
Betulinic acid 10 to 15μM on day4 R05 exp222	1.72
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.83
BRD2 inhibitor II 20μM R07 exp341	1.88
FK-506 5μM R07 exp358	1.93
Aminopterin 0.005μM R07 exp335	2.05
Thalidomide 20μM R07 exp406	2.05

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DNA recombination
protein deubiquitination
protein modification by small protein removal
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
protein modification by small protein conjugation or removal
proteolysis
cellular response to stress