INO80E [The Human Chemical-Genetic Interaction Map Project]

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======= INO80E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INO80E
  * **<color #00a2e8>Official Name</color>**: INO80 complex subunit E
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283899|283899]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NBZ0|Q8NBZ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INO80E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INO80E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ino80 complex|
|chromatin remodeling|
|DNA recombination|
|protein deubiquitination|
|protein modification by small protein removal|
|DNA repair|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|nucleolus|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|proteolysis|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.45|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.37|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.32|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.3|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.22|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.18|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.15|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.11|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.1|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.05|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.01|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.87|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.84|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.79|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.77|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.77|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.7|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.72|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.74|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.81|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.82|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.87|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.94|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.94|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.98|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.06|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.1|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.39|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|3.56|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|3.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfpt|TFPT]]|0.648|
|[[:human genes:u:uchl5|UCHL5]]|0.568|
|[[:human genes:n:nfrkb|NFRKB]]|0.559|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.557|
|[[:human genes:m:mbtd1|MBTD1]]|0.506|
|[[:human genes:i:ino80|INO80]]|0.473|
|[[:human genes:h:hdac2|HDAC2]]|0.439|
|[[:human genes:c:ccnf|CCNF]]|0.43|
|[[:human genes:s:smg7|SMG7]]|0.426|
|[[:human genes:v:vasn|VASN]]|0.411|
|[[:human genes:t:tbrg1|TBRG1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4198
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INO80E Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>