INO80E

Entrez Summary: N/A
UniProt Summary: Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Brefeldin A 0.02μM R00 exp8	-2.45
5-Fluorouracil 20μM R00 exp2	-2.37
Methotrexate 0.01μM R08 exp501	-2.32
Etoposide 0.3μM R05 exp199	-2.3
TRAIL 50ng/ml R00 exp36	-2.22
Aphidicolin 0.4μM R08 exp440	-2.18
Etoposide 1μM R00 exp19	-2.15
Hinokiflavone 12μM R08 exp487	-2.11
AICAR 240μM R05 exp211	-2.1
Nocodazole 0.2μM R02 exp64	-2.05
CR131-b 0.005μM R08 exp474	-2.01
LLY-283 2.6μM R06 exp290	-1.87
Mitomycin-C 0.06μM R08 exp503	-1.84
Artemisinin 50μM R08 exp450	-1.79
HMS-I2 5μM R06 exp287	-1.77
Rotenone 20μM R00 exp34	-1.77
THZ531 0.225μM R08 exp444	1.7
BI-2536 0.0042μM R03 exp95	1.72
Bisphenol F 50μM R08 exp457	1.74
Dimethyloxaloylglycine 100μM R05 exp229	1.81
Colchicine 0.009μM R05 exp215	1.82
I-BRD9 4μM R07 exp365	1.87
LY2090314 0.003μM R08 exp499	1.94
LY2090314 0.003μM R08 exp500 no dilution day6	1.94
UMK57 1μM R01 exp59	1.98
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.06
THZ531 0.11μM R07 exp409	2.1
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.39
THZ531 0.11 to 0.175μM on day4 R07 exp413	3.56
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	3.83

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ino80 complex
chromatin remodeling
DNA recombination
protein deubiquitination
protein modification by small protein removal
DNA repair
chromatin organization
DNA metabolic process
cellular response to DNA damage stimulus
nucleolus
protein modification by small protein conjugation or removal
chromosome organization
proteolysis
cellular response to stress