INPP5J [The Human Chemical-Genetic Interaction Map Project]

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======= INPP5J =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INPP5J
  * **<color #00a2e8>Official Name</color>**: inositol polyphosphate-5-phosphatase J
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27124|27124]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15735|Q15735]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INPP5J&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INPP5J|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606481|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Exo endo phos|
|CALCOCO1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|
|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|
|inositol-polyphosphate 5-phosphatase activity|
|inositol-1,4,5-trisphosphate 5-phosphatase activity|
|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|
|negative regulation of microtubule polymerization|
|inositol phosphate dephosphorylation|
|phosphorylated carbohydrate dephosphorylation|
|inositol phosphate catabolic process|
|phosphatidylinositol dephosphorylation|
|polyol catabolic process|
|negative regulation of peptidyl-serine phosphorylation|
|phospholipid dephosphorylation|
|dendritic shaft|
|negative regulation of microtubule polymerization or depolymerization|
|regulation of microtubule polymerization|
|alcohol catabolic process|
|inositol phosphate metabolic process|
|negative regulation of protein polymerization|
|organic hydroxy compound catabolic process|
|regulation of microtubule polymerization or depolymerization|
|ruffle|
|phosphatidylinositol biosynthetic process|
|polyol metabolic process|
|organophosphate catabolic process|
|growth cone|
|negative regulation of protein complex assembly|
|SH3 domain binding|
|negative regulation of supramolecular fiber organization|
|regulation of peptidyl-serine phosphorylation|
|negative regulation of cytoskeleton organization|
|negative regulation of neuron projection development|
|phosphatidylinositol metabolic process|
|cellular carbohydrate metabolic process|
|negative regulation of cell projection organization|
|regulation of microtubule cytoskeleton organization|
|lipid modification|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|negative regulation of neuron differentiation|
|phospholipid biosynthetic process|
|negative regulation of neurogenesis|
|glycerophospholipid metabolic process|
|dephosphorylation|
|negative regulation of nervous system development|
|alcohol metabolic process|
|negative regulation of cell development|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|negative regulation of protein phosphorylation|
|small molecule catabolic process|
|negative regulation of phosphorylation|
|regulation of protein complex assembly|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|regulation of neuron projection development|
|organophosphate biosynthetic process|
|regulation of cytoskeleton organization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|lipid biosynthetic process|
|negative regulation of protein modification process|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|organophosphate metabolic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|regulation of organelle organization|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|neurogenesis|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.71|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5105
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INPP5J Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>