INPP5J

Gene Information

Official Symbol: INPP5J
Official Name: inositol polyphosphate-5-phosphatase J
Aliases and Previous Symbols: N/A
Entrez ID: 27124
UniProt: Q15735
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5105
Expression level (log2 read counts): -6.6

Expression Distribution

Screen	Score
Etoposide 1μM R00 exp19	-1.71
CB-839 10μM R05 exp224	1.74

Exo endo phos
CALCOCO1

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
inositol-1,4,5-trisphosphate 5-phosphatase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
negative regulation of microtubule polymerization
inositol phosphate dephosphorylation
phosphorylated carbohydrate dephosphorylation
inositol phosphate catabolic process
phosphatidylinositol dephosphorylation
polyol catabolic process
negative regulation of peptidyl-serine phosphorylation
phospholipid dephosphorylation
dendritic shaft
negative regulation of microtubule polymerization or depolymerization
regulation of microtubule polymerization
alcohol catabolic process
inositol phosphate metabolic process
negative regulation of protein polymerization
organic hydroxy compound catabolic process
regulation of microtubule polymerization or depolymerization
ruffle
phosphatidylinositol biosynthetic process
polyol metabolic process
organophosphate catabolic process
growth cone
negative regulation of protein complex assembly
SH3 domain binding
negative regulation of supramolecular fiber organization
regulation of peptidyl-serine phosphorylation
negative regulation of cytoskeleton organization
negative regulation of neuron projection development
phosphatidylinositol metabolic process
cellular carbohydrate metabolic process
negative regulation of cell projection organization
regulation of microtubule cytoskeleton organization
lipid modification
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
regulation of microtubule-based process