INSL3

Entrez Summary: This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012].
UniProt Summary: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

insulin receptor binding
positive regulation of wound healing
positive regulation of response to wounding
G protein-coupled receptor binding
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
hormone activity
protease binding
regulation of wound healing
positive regulation of epithelial cell migration
regulation of response to wounding
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of epithelial cell migration
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
signaling receptor binding
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
spermatogenesis
positive regulation of locomotion
male gamete generation
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
regulation of cell migration
regulation of cell motility
regulation of locomotion
regulation of cellular component movement
multi-organism reproductive process
cell-cell signaling
G protein-coupled receptor signaling pathway
reproductive process
reproduction
regulation of response to stress
extracellular space
positive regulation of multicellular organismal process
extracellular region