INTS3 [The Human Chemical-Genetic Interaction Map Project]

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======= INTS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTS3
  * **<color #00a2e8>Official Name</color>**: integrator complex subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65123|65123]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q68E01|Q68E01]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INTS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INTS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611347|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2356|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SOSS complex|
|integrator complex|
|snRNA processing|
|snRNA metabolic process|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|response to ionizing radiation|
|mitotic cell cycle checkpoint|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle|
|ncRNA processing|
|response to radiation|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|DNA repair|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mitotic cell cycle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|nucleolus|
|RNA processing|
|cell cycle process|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|organic cyclic compound biosynthetic process|
|cell cycle|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.63|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.52|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.38|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.23|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.22|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.18|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-2.18|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.15|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.1|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.09|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-2.02|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.98|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.96|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.91|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.89|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.89|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.85|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.82|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.81|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.78|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.77|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.73|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.71|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.7|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.91|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.97|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 144
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INTS3 Expression in NALM6 Cells: 6.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>