INTS3

Entrez Summary: The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.63
Deferoxamine 11μM R07 exp350	-2.52
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.38
BI-D1870 3.15μM R02 exp66	-2.23
Thapsigargin 0.005μM R07 exp407	-2.22
NMS-873 0.07μM R07 exp380	-2.18
Tenofovir 10μM R07 exp405	-2.18
Parthenolide 2.5μM R05 exp238	-2.15
Senexin-A 25μM R07 exp400	-2.1
UM0125461 0.74μM R02 exp84	-2.09
Zebularine 20μM R07 exp423	-2.02
LY2090314 0.003μM R08 exp500 no dilution day6	-1.98
Tubastatin-A 2.5μM R07 exp417	-1.96
Rapamycin 2μM R07 exp306	-1.91
Rucaparib 6.5μM R08 exp520	-1.89
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.89
Dimethyloxaloylglycine 100μM R05 exp229	-1.85
Pterostilbene 16μM R02 exp78	-1.82
Latrunculin-B 10μM R07 exp374	-1.81
Genistein 15μM R07 exp360	-1.78
PF-06409577 20μM R07 exp389	-1.77
Resminostat 0.5μM R07 exp393	-1.73
Calcipotriol 5μM R08 exp464	-1.71
Palbociclib 1μM R07 exp382	-1.7
MKC9989 10μM R03 exp133	1.91
Actinomycin-D 0.01μM R00 exp4	1.97
Bortezomib 0.05μM R00 exp7	2.1

Global Fraction of Cell Lines Where Essential: 733/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	31/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	74/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

SOSS complex
integrator complex
snRNA processing
snRNA metabolic process
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
response to ionizing radiation
mitotic cell cycle checkpoint
cell cycle checkpoint
negative regulation of mitotic cell cycle
ncRNA processing
response to radiation
ncRNA metabolic process
transcription by RNA polymerase II
DNA repair
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mitotic cell cycle
DNA metabolic process
cellular response to DNA damage stimulus
nucleolus
RNA processing
cell cycle process
nucleobase-containing compound biosynthetic process
response to abiotic stimulus
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
organic cyclic compound biosynthetic process
cell cycle
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process