INTS7 [The Human Chemical-Genetic Interaction Map Project]

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======= INTS7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTS7
  * **<color #00a2e8>Official Name</color>**: integrator complex subunit 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25896|25896]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVH2|Q9NVH2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INTS7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INTS7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrator complex|
|snRNA 3-end processing|
|snRNA processing|
|snRNA metabolic process|
|ncRNA 3-end processing|
|cellular response to ionizing radiation|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|chromosome|
|DNA damage checkpoint|
|RNA 3-end processing|
|DNA integrity checkpoint|
|response to ionizing radiation|
|cellular response to radiation|
|cell cycle checkpoint|
|nuclear body|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|ncRNA processing|
|response to radiation|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|negative regulation of cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to DNA damage stimulus|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.8|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.9|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.607|
|[[:human genes:i:ints8|INTS8]]|0.423|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 446/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|18/28|
|bone|15/26|
|breast|18/33|
|central nervous system|35/56|
|cervix|1/4|
|colorectal|11/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|7/21|
|liver|7/20|
|lung|43/75|
|lymphocyte|9/16|
|ovary|19/26|
|pancreas|13/24|
|peripheral nervous system|7/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|13/22|
|urinary tract|14/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2463
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INTS7 Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>