INTS7

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 446/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	15/28
blood	18/28
bone	15/26
breast	18/33
central nervous system	35/56
cervix	1/4
colorectal	11/17
esophagus	7/13
fibroblast	1/1
gastric	11/16
kidney	7/21
liver	7/20
lung	43/75
lymphocyte	9/16
ovary	19/26
pancreas	13/24
peripheral nervous system	7/16
plasma cell	12/15
prostate	1/1
skin	17/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	13/22
urinary tract	14/29
uterus	1/5

Expression Distribution

Gene	Correlation
HGC6.3	0.607
INTS8	0.423

integrator complex
snRNA 3-end processing
snRNA processing
snRNA metabolic process
ncRNA 3-end processing
cellular response to ionizing radiation
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
chromosome
DNA damage checkpoint
RNA 3-end processing
DNA integrity checkpoint
response to ionizing radiation
cellular response to radiation
cell cycle checkpoint
nuclear body
cellular response to environmental stimulus
cellular response to abiotic stimulus
ncRNA processing
response to radiation
ncRNA metabolic process
transcription by RNA polymerase II
negative regulation of cell cycle
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
cellular response to DNA damage stimulus
RNA processing
nucleobase-containing compound biosynthetic process
response to abiotic stimulus
heterocycle biosynthetic process
aromatic compound biosynthetic process
regulation of cell cycle
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process